Bioburden Monitoring (Real Time)

METTLER TOLEDO Thornton’s RMS8120i Real-Time Microbial Analyzer provides continuous, on-line monitoring of microbial contamination (bioburden) in pharmaceutical water systems, including Purified Water (PW) and Water for Injection (WFI).

Featuring patented BioSure™ laser-induced fluorescence (LIF) technology, the RMS8120i detects and counts individual microorganisms in seconds as they pass through a continuous sample stream, including viable but non-culturable (VBNC) microorganisms. Unlike traditional culture-based methods, the analyzer provides real-time results without waiting days for laboratory plate counts, enabling faster identification of changes in microbial activity.

The RMS8120i integrates with METTLER TOLEDO’s multi-parameter M800 transmitter platform, allowing facilities to monitor bioburden alongside other critical water quality parameters, including TOC, conductivity, and ozone. Primary validation testing has been completed according to EP, USP, and PDA TR33 guidance, while field serviceability and Intelligent Sensor Management (ISM) predictive maintenance help maximize uptime.

With continuous visibility into microbial activity, the RMS8120i supports proactive process control, faster response to contamination, and more informed decisions about water system sanitization and microbial testing.

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