Single Use Tangential Flow Filtration System (TFF)
An Agilitech single use tangential flow filtration system (TFF) provides the flexibility and agility to perform purification operations upon delivery. The fit-for-purpose design offers options and possibilities for every facet of the TFF skid. Our engineering experts collaborate with you to design a system that meets your needs today and in the future—whether adding or removing inlets/outlets, analytics, filters, etc. The TFF system provides unmatched flexibility for components: choose your preferred filter brand, single-use assembly, bag or bottle recirculation container, and more.
Agilitech TFF systems are available in a range of fixed sizes for lab to production environments:
Agilitech Tech Specs
Benchtop Systems
| Attribute | T125 | T250 |
|---|---|---|
| General Skid Specifications | ||
| Tubing Internal Diameter | Feed and Retentate: 0.125 in Permeate: 0.125 in Inlets: 0.125 in | Feed and Retentate: 0.25 in Permeate: 0.25 in Inlets: 0.25 in |
| Feed Flow Rate | 1-500 mL/min | 0.5-7.7 LPM |
| Tank Size | Up to 10L | Up to 50L |
| Pressure rating | 60 psi/4 bar | 60 psi/4 bar |
| Temperature Range | 2–50°C | 2-50°C |
| Humidity (non-condensing) | 10-90% | 10-90% |
| Utility Requirements* | 100-120 VAC | 100-120 VAC |
| Wetted Materials | USP <88> Class VI and animal free | USP <88> Class VI and animal free |
| Membrane Holder Capacity | 0.01 m2 to 0.04 m2 | 0.01m2 to 2.0 m2 |
| Feed and Filtrate Flow Measurement | Clamp on ultrasonic flow sensor (±3%) | Clamp on ultrasonic flow sensor (±3%) |
| Inlets | 1 product 2 buffers | 1 product 2 buffers |
| Outlet Ports | 1 Filtrate | 1 Filtrate |
| Minimum Working Volume Agitator Top Agitator Bottom Bag Sensors/Sampling | Depends on mixer selected | Depends on mixer selected |
| Hold-Up Volume (excludes filtration device) | 25 mL | 50 mL |
| Dims (W x D x H)** | 635 x 559 x 635 mm | 635 x 559 x 635 mm |
| Sensor Performance | ||
| Pressure | 0-6 psi (± 2%) 6-30 psi (± 3%) 30-60 psi (± 5%) | 0-6 psi (± 2%) 6-30 psi (± 3%) 30-60 psi (± 5%) |
| Filtrate Conductivity | 0-100 mS/cm (± 3%) | 0-100 mS/cm (± 3%) |
| Vessel Weight | 0-10 kg (± 0.3%) | 0-50 kg (± 0.3%) |
| Flow | 0-4 LPM (± 3%) | 0-8 LPM (± 3%) |
Large Scale Systems
| Attribute | T500 | T750 | T1000 |
|---|---|---|---|
| General Skid Specifications | |||
| Tubing Internal Diameter | Feed and Retentate: 0.50 in Permeate: 0.25 in Inlets: 0.25 in | Feed and retentate: 0.75 in Permeate: 0.5 in Inlets: 0.5 in | Feed and retentate tubing: 1 in Permeate: 0.75 in Inlets: 0.75 in |
| Tank Size | Up to 200L | Up to 650 L | Up to 1000 L |
| Feed Flow Rate | 0-10 LPM | 5 – 50 LPM | 10 – 100 LPM |
| Pressure rating | 60 psi/4 bar | 60 psi/4 bar | 60 psi/4 bar |
| Temperature Range | 2-50°C | 2 – 50°C | 2 – 50°C |
| Humidity (non-condensing) | 10-90% | 10 – 90% | 10 – 90% |
| Utility Requirements* Skid Power Mixer Power | 100-120 VAC | 220-230 VAC 100 – 120 VAC | 220-230 VAC 100 – 120 VAC |
| Wetted Materials | USP <88> Class VI and animal free | USP <88> Class VI and animal free | USP <88> Class VI and animal free |
| Membrane Holder Capacity | 0.5m2 to 5.0m2 | 0.5m2 to 5.0m2 | 2.5m2 to 10.0m2 |
| Feed and Filtrate Flow Measurement | Clamp on ultrasonic flow sensor (±3%) | Clamp on ultrasonic flow sensor (±3%) | Clamp on ultrasonic flow sensor (±3%) |
| Temp Control | 2-50°C | 2 – 50°C | 2 – 50°C |
| Inlets | 1 product 2 buffers | 1 product 2 buffers | To recirc bag: 3 inlets, 1 product, 2 buffers To feed pump: 3 inlets, 1 recirculating bag, 2 additional feed ports |
| Outlet Ports | 1 Filtrate | 1 Filtrate | Permeate: 2 outlets; waste or recycle Retentate; 3 outlets waste, recycle or recirculating bag |
| Minimum Working Volume Agitator Top Agitator Bottom Bag Sensors/Sampling | Depends on mixer selected | Based on 2OO L Bag 37 L 14 L 25 L | Based on 650 L Bag 82 L 31 L 55 L |
| Hold-Up Volume (excludes filtration device) | 750 mL | 1.5 L | 2.5 L |
| Dims (W x D x H)** Skid Bag Holder | 1219 x 787 x 1810 mm 1219 x 825 x 1595 mm | 1219 x 787 x 1810 mm 1219 x 825 x 1595 mm | 2032 x 1270 x 2108 1371 x 1066 x 1595 |
| Sensor Performance | |||
| Pressure | 0-6 psi (± 2%) 6-30 psi (± 3%) 30-60 psi (± 5%) | 0 – 6 psi (± 2%) 6 – 30 psi (± 3%) 30 – 60 psi (± 5%) | 0 – 6 psi (± 2%) 6 – 30 psi (± 3%) 30 – 60 psi (± 5%) |
| Filtrate Conductivity | 0-250 mS/cm (±0.25 mS/cm) | 0-250 mS/cm (±0.25 mS/cm) | 0-250 mS/cm (± 0.25 mS/cm) |
| Vessel Weight | 0-200 kg (± 0.3%) | 0 -650 kg (± 3%) | 0-1000 kg (± 0.3%) |
| Flow | 0-10 LPM (± 3%) | 0-50 LPM (± 3%) | 0 – 100 LPM (± 3%) |
Agilitech TFF Skids
T750: Lab to Pilot TFF System
A unique open system design provides complete flexibility to meet your current application needs, while future-proofing the system to easily and cost-effectively scale along with your process.
T1000: Production TFF System
This Agilitech single use tangential flow filtration system is designed to streamline your bioprocess, increase sample recovery, and reduce the cost of consumables. Every part of the single use filtration system features best-in-class components to optimize performance, providing users distinct advantages when compared to similar systems.
Optimal transmembrane pressure is maintained to optimize filter performance throughout the filtration process. Combined with an air modulated diaphragm pressure control valve, retentate pressure reaches set point quickly to achieve the desired TMP, eliminating pump pulsations and pinching control valves.
The Agilitech TFF system is uniquely designed to limit shear on product, maximizing yield. It maximizes product recovery in the recirculation bag as users can easily disconnect the tubing from the TFF skid and transfer the recirculation bag to the next step for further processing. The result: fewer consumables, reduced cost, and the elimination of project delays resulting from supply chain issues with consumables.
The Single-use TFF System is offered in two models. The T750 has a 250 L tank capacity, and the T1000 has a tank size of up to 1000 L. Both models feature an open system design to provide complete flexibility for our expert engineers to adapt the TFF skid to meet specific user requirements.
Integration Services
- Seamless integration of stand-alone lab equipment into a single system, improving data integrity and driving operational efficiency.
- Specialized expertise integrating equipment from different manufacturers into a single system with flexible automation and centralized control.
Automation Engineering and Implementation
- Design and implement state-of-the-art bioprocess automation solutions that maximize operational efficiencies and minimize risk based upon S88 standards.
- Deliver flexible automation platform and management information system tailored to your current process and easily optimized as your needs change.
- Support your preferred platform, whether DeltaV, Rockwell Automation, Wonderware or other.
CONTACT US – WE CAN HELP YOU SELECT THE PROPER COMPONENTS FOR YOUR APPLICATION!
Description
Contact Us
Optimal Biotech Group
131 Industrial Road
Unit 7
Belmont, CA 94002
Phone: (650) 376-3837
Fax: (866) 941-6822
Email: pcharnas@optimalbiotech.com
