Viable Biomass Sensor
Dielectric spectroscopy, more commonly known as capacitance measurement, has been routinely used in the industry and academia for real time cell density measurement for over three decades.
This technology from ABER offers real time inline measurement, without the need to take offline samples. Capacitance measurement is seen as a valuable key performance indicator or a critical process parameter, that is not only used to monitor the process, but also to automatically control important events during the run.
As the industry moves towards single-use facilities, it is crucial that a PAT technology such as capacitance is available across different platforms. Building on Aber’s experience with single-use capacitance sensors, the latest FUTURA Neo single-use viable biomass sensor has been specifically developed for integration into Thermo Scientifc™ BioProcess Containers (BPCs) for use in Thermo Scientifc™ HyPerforma™ S.U.B.s.
ABER Instruments develops and manufactures dielectric technology used to monitor biomass. By measuring cell membrane capacitance and media conductivity, sensors are used to determine live cell concentration online within small and large-scale bioreactor processes.
Cells with intact plasma membranes can be considered to act as tiny capacitors under the influence of an electric field. The non-conducting nature of the plasma membrane allows a build-up of charge. The resulting capacitance can be measured: it is dependent upon the cell type and is directly proportional to the membrane bound volume of these viable cells.
Widely adopted by the world’s leading biotech companies in both R&D and cGMP, ABER’s products are small and light but deliver powerful capabilities and great application flexibility. The FUTURA system’s three primary hardware components are: The Probe, the FUTURA Instrument (Head Amplifier), and the Transmitter.
Optimal Biotech Group and ABER Instruments are service-oriented vendors. We will assist in providing demos and follow up with data review, providing full confidential documentation of results. You will receive qualitative and quantitative analysis from our team. We work as your partner in product development and production, providing out-of-house expertise and ongoing applications assistance.