Single Use Tangential Flow Filtration System (TFF)

An Agilitech single use tangential flow filtration system (TFF) provides the flexibility and agility to perform purification operations upon delivery. The fit-for-purpose design offers options and possibilities for every facet of the TFF skid. Our engineering experts collaborate with you to design a system that meets your needs today and in the future—whether adding or removing inlets/outlets, analytics, filters, etc. The TFF system provides unmatched flexibility for components: choose your preferred filter brand, single-use assembly, bag or bottle recirculation container, and more.

Agilitech TFF systems are available in a range of fixed sizes for lab to production environments:

Agilitech Tech Specs

Benchtop Systems
AttributeT125T250
General Skid Specifications
Tubing Internal DiameterFeed and Retentate: 0.125 in
Permeate: 0.125 in
Inlets: 0.125 in
Feed and Retentate: 0.25 in
Permeate: 0.25 in
Inlets: 0.25 in
Feed Flow Rate1-500 mL/min0.5-7.7 LPM
Tank SizeUp to 10LUp to 50L
Pressure rating60 psi/4 bar60 psi/4 bar
Temperature Range2–50°C2-50°C
Humidity (non-condensing)10-90%10-90%
Utility Requirements*100-120 VAC100-120 VAC
Wetted MaterialsUSP <88> Class VI and animal freeUSP <88> Class VI and animal free
Membrane Holder Capacity0.01 m2 to 0.04 m20.01m2 to 2.0 m2
Feed and Filtrate Flow MeasurementClamp on ultrasonic flow sensor (±3%)Clamp on ultrasonic flow sensor (±3%)
Inlets1 product
2 buffers
1 product
2 buffers
Outlet Ports1 Filtrate1 Filtrate
Minimum Working Volume
Agitator Top
Agitator Bottom
Bag Sensors/Sampling
Depends on mixer selectedDepends on mixer selected
Hold-Up Volume (excludes filtration device)25 mL50 mL
Dims (W x D x H)**635 x 559 x 635 mm635 x 559 x 635 mm
Sensor Performance
Pressure0-6 psi (± 2%)
6-30 psi (± 3%)
30-60 psi (± 5%)
0-6 psi (± 2%)
6-30 psi (± 3%)
30-60 psi (± 5%)
Filtrate Conductivity0-100 mS/cm (± 3%)0-100 mS/cm (± 3%)
Vessel Weight0-10 kg (± 0.3%)0-50 kg (± 0.3%)
Flow0-4 LPM (± 3%)0-8 LPM (± 3%)
Large Scale Systems
AttributeT500T750T1000
General Skid Specifications   
Tubing Internal DiameterFeed and Retentate: 0.50 in
Permeate: 0.25 in
Inlets: 0.25 in
Feed and retentate: 0.75 in
Permeate: 0.5 in
Inlets: 0.5 in
Feed and retentate tubing: 1 in
Permeate: 0.75 in
Inlets: 0.75 in
Tank SizeUp to 200LUp to 650 LUp to 1000 L
Feed Flow Rate0-10 LPM5 – 50 LPM10 – 100 LPM
Pressure rating60 psi/4 bar60 psi/4 bar60 psi/4 bar
Temperature Range2-50°C2 – 50°C2 – 50°C
Humidity (non-condensing)10-90%10 – 90%10 – 90%
Utility Requirements*
Skid Power
Mixer Power
 
100-120 VAC
 
220-230 VAC
100 – 120 VAC
 
220-230 VAC
100 – 120 VAC
Wetted MaterialsUSP <88> Class VI and animal freeUSP <88> Class VI and animal freeUSP <88> Class VI and animal free
Membrane Holder Capacity0.5m2 to 5.0m20.5m2 to 5.0m22.5m2 to 10.0m2
Feed and Filtrate Flow MeasurementClamp on ultrasonic flow sensor (±3%)Clamp on ultrasonic flow sensor (±3%)Clamp on ultrasonic flow sensor (±3%)
Temp Control2-50°C2 – 50°C2 – 50°C
Inlets1 product
2 buffers
1 product
2 buffers
To recirc bag: 3 inlets, 1 product, 2 buffers
To feed pump: 3 inlets, 1 recirculating bag, 2 additional feed ports
Outlet Ports1 Filtrate1 FiltratePermeate: 2 outlets; waste or recycle
Retentate; 3 outlets waste, recycle or recirculating bag
Minimum Working Volume
Agitator Top
Agitator Bottom
Bag Sensors/Sampling
Depends on mixer selectedBased on 2OO L Bag
37 L
14 L
25 L
Based on 650 L Bag
82 L
31 L
55 L
Hold-Up Volume
(excludes filtration device)
750 mL1.5 L2.5 L
Dims (W x D x H)**
Skid Bag Holder
1219 x 787 x 1810 mm
1219 x 825 x 1595 mm
1219 x 787 x 1810 mm
1219 x 825 x 1595 mm
2032 x 1270 x 2108
1371 x 1066 x 1595
Sensor Performance   
Pressure0-6 psi (± 2%)
6-30 psi (± 3%)
30-60 psi (± 5%)
0 – 6 psi (± 2%)
6 – 30 psi (± 3%)
30 – 60 psi (± 5%)
0 – 6 psi (± 2%)
6 – 30 psi (± 3%)
30 – 60 psi (± 5%)
Filtrate Conductivity0-250 mS/cm (±0.25 mS/cm)0-250 mS/cm (±0.25 mS/cm)0-250 mS/cm (± 0.25 mS/cm)
Vessel Weight0-200 kg (± 0.3%)0 -650 kg (± 3%)0-1000 kg (± 0.3%)
Flow0-10 LPM (± 3%)0-50 LPM (± 3%)0 – 100 LPM (± 3%)

Agilitech TFF Skids

T750: Lab to Pilot TFF System

Single Use Tangential Flow Filtration System Agilitech
A unique open system design provides complete flexibility to meet your current application needs, while future-proofing the system to easily and cost-effectively scale along with your process.

T1000: Production TFF System

T1000 single-use tangential flow filtration system for large scale manufacturing

This Agilitech single use tangential flow filtration system is designed to streamline your bioprocess, increase sample recovery, and reduce the cost of consumables. Every part of the single use filtration system features best-in-class components to optimize performance, providing users distinct advantages when compared to similar systems.

Optimal transmembrane pressure is maintained to optimize filter performance throughout the filtration process. Combined with an air modulated diaphragm pressure control valve, retentate pressure reaches set point quickly to achieve the desired TMP, eliminating pump pulsations and pinching control valves.

The Agilitech TFF system is uniquely designed to limit shear on product, maximizing yield. It maximizes product recovery in the recirculation bag as users can easily disconnect the tubing from the TFF skid and transfer the recirculation bag to the next step for further processing. The result: fewer consumables, reduced cost, and the elimination of project delays resulting from supply chain issues with consumables.

The Single-use TFF System is offered in two models. The T750 has a 250 L tank capacity, and the T1000 has a tank size of up to 1000 L. Both models feature an open system design to provide complete flexibility for our expert engineers to adapt the TFF skid to meet specific user requirements.

Integration Services

  • Seamless integration of stand-alone lab equipment into a single system, improving data integrity and driving operational efficiency.
  • Specialized expertise integrating equipment from different manufacturers into a single system with flexible automation and centralized control.

Automation Engineering and Implementation

  • Design and implement state-of-the-art bioprocess automation solutions that maximize operational efficiencies and minimize risk based upon S88 standards.
  • Deliver flexible automation platform and management information system tailored to your current process and easily optimized as your needs change.
  • Support your preferred platform, whether DeltaV, Rockwell Automation, Wonderware or other.

View all Agilitech Products

CONTACT US – WE CAN HELP YOU SELECT THE PROPER COMPONENTS FOR YOUR APPLICATION!

Call (650) 376-3837

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